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Immune checkpoint inhibitors (cpis) are a relatively newly licenced cancer treatment, which make a once previously untreatable disease now amenable to a potential cure. In the colon, icis trigger resident and circulating t cell activation and infiltration of myeloid cells. Immune checkpoint inhibitors (cpi) could effectively target cancers that are resistant to traditional therapy but may initiate immune related adverse effects, such as colitis.

Crucially, these pathogenic, polyfunctional t cells share features with colonic t cell clusters described in patients with cpi colitis and resemble t cell phenotypes observed in.

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